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Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

null

《医学前沿（英文）》 2013年 第7卷 第3期   页码 306-315 doi: 10.1007/s11684-013-0279-x

摘要：

Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective options for hematological malignancies, and human leukocyte antigen-partially matched related donors (PMRDs) are a valuable option for HSCT. Several protocols (with or without ex vivo T-cell depletion (TCD)) have been established worldwide. TCD including CD34+positive selection and CD3/CD19 depletion has successfully overcome the human leukocyte antigen disparity. However, TCD is associated with prolonged immune deficiencies, increased risks of infectious complications, and high transplantation-related mortality. PMRD HSCT without ex vivo TCD is well developed, and numerous patients have benefitted from it. Here, we review the literature on PMRD HSCT.

关键词： partially matched related donor     hematopoietic stem cell transplantation     allogeneic    

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event-free patients receiving haploidentical allografts and those receiving human leukocyte antigen-matchedsibling donor allografts

null

《医学前沿（英文）》 2018年 第12卷 第2期   页码 153-163 doi: 10.1007/s11684-017-0548-1

摘要：

To establish optimal reference values for recovered immune cell subsets, we prospectively investigated post-transplant immune reconstitution (IR) in 144 patients who received allogeneic stem cell transplantation (allo-SCT) and without showing any of the following events: poor graft function, grades II?IV acute graft-versus-host disease (GVHD), serious chronic GVHD, serious bacterial infection, invasive fungal infection, or relapse or death in the first year after transplantation. IR was rapid in monocytes, intermediate in lymphocytes, CD3+ T cells, CD8+ T cells, and CD19+ B cells, and very slow in CD4+ T cells in the entire patient cohort. Immune recovery was generally faster under HLA-matched sibling donor transplantation than under haploidentical transplantation. Results suggest that patients with an IR comparable to the reference values display superior survival, and the levels of recovery in immune cells need not reach those in healthy donor in the first year after transplantation. We suggest that data from this recipient cohort should be used as reference values for post-transplant immune cell counts in patients receiving HSCT.

关键词： immune reconstitution     hematopoietic stem cell transplantation     event-free patients     reference range    

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Fate of microplastics in a coastal wastewater treatment plant: Microfibers could partially break through

《环境科学与工程前沿（英文）》 2022年 第16卷 第7期 doi: 10.1007/s11783-021-1517-0

摘要：

• Fate of microplastics in integrated membrane system for water reuse was investigated.

关键词： Water reclamation     Integrated membrane system     Microplastics     Removal     Coastal zone    

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The influence of brain death on donor liver and the potential mechanisms of protective intervention

null

《医学前沿（英文）》 2011年 第5卷 第1期   页码 8-14 doi: 10.1007/s11684-011-0109-y

摘要：

Brain-dead donors have become one of the main sources of organs for transplantation in Western countries. The quality of donor organs is closely related to the outcome of the transplantation. Experimental studies have confirmed the inferior graft survival of livers from brain-dead donors compared with those from living donors. Studies conducted in the past 10 years have shown that brain death is associated with effects on the decreased donor organ quality. However, whether the decrease in the viability of donor organs is caused by brain death or by the events before and after brain death remains uncertain. The purpose of this review is to introduce the advances and controversies regarding the influence of brain death on the viability of donor livers and to summarize the mechanisms of the different protective interventions for donor livers.

关键词： brain death     donor liver    

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Design and analysis of partially decoupled translational parallel mechanisms with single-loop structures

《机械工程前沿（英文）》 2022年 第17卷 第3期 doi: 10.1007/s11465-022-0695-1

摘要： This study presents a family of novel translational parallel mechanisms (TPMs) with single-loop topological structures. The proposed mechanism consists of only revolute and prismatic joints. The novel TPMs are simpler in structure and have fewer joints and components than the well-known Delta Robot. Four types of 2-degree of freedom driving systems are applied to different limb structures to avoid the moving actuator that causes the problem of increased moving mass. Four sample TPMs are constructed using the synthesized limbs, and one of them is investigated in terms of kinematic performance. First, a position analysis is performed and validated through numerical simulation to reveal the characteristics of partially decoupled motion, which improves the controllability of TPM. Second, singular configurations are identified, and the resulting singularity curve is obtained. Lastly, the workspace of TPM is analyzed, and the relationship between the singular configurations and the reachable workspace is explored. The workspace of the 3-CRR (C denotes the cylindrical joint and R denotes the revolute joint) translational mechanism is also presented to prove that the proposed TPM has a fairly large workspace.

关键词： translational parallel mechanism     single loop     multiple driving system     workspace analysis     singularity    

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Regulation of radicals by hydrogen-donor solvent in direct coal liquefaction

《化学科学与工程前沿（英文）》 2022年 第16卷 第12期   页码 1689-1699 doi: 10.1007/s11705-022-2186-7

摘要： Radicals are important intermediates in direct coal liquefaction. Certain radicals can cause the cleavage of chemical bonds. At high temperatures, radical fragments can be produced by the splitting of large organic molecules, which can break strong chemical bonds through the induction pyrolysis of radicals. The reaction between the formation and annihilation of coal radical fragments and the effect of hydrogen-donor solvents on the radical fragments are discussed in lignite hydrogenolysis. Using the hydroxyl and ether bonds as indicators, the effects of different radicals on the cleavage of chemical bond were investigated employing density functional theory calculations and lignite hydrogenolysis experiments. Results showed that the adjustment of the coal radical fragments could be made by the addition of hydrogen-donor solvents. Results showed that the transition from coal radical fragment to H radical leads to the variation of product distribution. The synergistic mechanism of hydrogen supply and hydrogenolysis of hydrogen-donor solvent was proposed.

关键词： direct coal liquefaction     hydrogen-donor solvent     induced pyrolysis     radical mechanism     density functional theory calculations    

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Enhanced photoelectrochemical water splitting with a donor-acceptor polyimide

《能源前沿（英文）》 doi: 10.1007/s11708-023-0910-8

摘要： Polyimide (PI) has emerged as a promising organic photocatalyst owing to its distinct advantages of high visible-light response, facile synthesis, molecularly tunable donor-acceptor structure, and excellent physicochemical stability. However, the synthesis of high-quality PI photoelectrode remains a challenge, and photoelectrochemical (PEC) water splitting for PI has been less studied. Herein, the synthesis of uniform PI photoelectrode films via a simple spin-coating method was reported, and their PEC properties were investigated using melamine as donor and various anhydrides as acceptors. The influence of the conjugate size of aromatic unit (phenyl, biphenyl, naphthalene, perylene) of electron acceptor on PEC performance were studied, where naphthalene-based PI photoelectrode exhibited the highest photocurrent response. This is resulted from the unification of wide-range light absorption, efficient charge separation and transport, and strong photooxidation capacity. This paper expands the material library of polymer films for PEC applications and contributes to the rational design of efficient polymer photoelectrodes.

关键词： polyimide (PI) film     photoelectrochemistry     band structure engineering     aromatic unit    

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Performance enhancement of partially shaded solar PV array using novel shade dispersion technique

Namani RAKESH,T. Venkata MADHAVARAM

《能源前沿（英文）》 2016年 第10卷 第2期   页码 227-239 doi: 10.1007/s11708-016-0405-y

摘要： Solar photo voltaic array (SPVA) generates a smaller amount of power than the standard rating of the panel due to the partial shading effect. Since the modules of the arrays receive different solar irradiations, the P-V characteristics of photovoltaic (PV) arrays contain multiple peaks or local peaks. This paper presents an innovative method (magic square) in order to increase the generated power by configuring the modules of a shaded photovoltaic array. In this approach, the physical location of the modules in the total cross tied (TCT) connected in the solar PV array is rearranged based on the magic square arrangement pattern. This connection is done without altering any electrical configurations of the modules in the PV array. This method can distribute the shading effect over the entire PV array, without concentrating on any row of modules and can achieve global peaks. For different types of shading patterns, the output power of the solar PV array with the proposed magic square configuration is compared with the traditional configurations and the performance is calculated. This paper presents a new reconfiguration technique for solar PV arrays, which increases the PV power under different shading conditions. The proposed technique facilitates the distribution of the effect of shading over the entire array, thereby, reducing the mismatch losses caused by partial shading. The theoretical calculations are tested through simulations in Matlab/Simulink to validate the results. A comparison of power loss for different types of topologies under different types of shading patterns for a 4 × 4 array is also explained.

关键词： photovoltaic cells     mismatch loss     shading patterns     partial shading     magic square     power enhancement     global peaks and total cross tied (TCT)    

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used as a salvage option for patients with relapsed acute leukemia post-chemotherapy plus modified donor

《医学前沿（英文）》 2021年 第15卷 第5期   页码 728-739 doi: 10.1007/s11684-021-0833-x

摘要： Relapse is the main problem after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The outcome of a second allo-HSCT (HSCT2) for relapse post-HSCT has shown promising results in some previous studies. However, little is known about the efficacy of HSCT2 in patients with relapsed/refractory acute leukemia (AL) post-chemotherapy plus modified donor lymphocyte infusion (post-Chemo+m-DLI) after the first allo-HSCT (HSCT1). Therefore, we retrospectively analyzed the efficacy of HSCT2 in 28 patients with relapsed/refractory AL post-Chemo+m-DLI in our center. With a median follow-up of 918 (457–1732) days, 26 patients (92.9%) achieved complete remission, and 2 patients exhibited persistent disease. The probabilities of overall survival (OS) and disease-free survival (DFS) 1 year after HSCT2 were 25.0% and 21.4%, respectively. The cumulative incidences of nonrelapse mortality on day 100 and at 1 year post-HSCT2 were 7.1%±4.9% and 25.0%±8.4%. The cumulative incidences of relapse were 50.0%±9.8% and 53.5%±9.9% at 1 and 2 years post-HSCT2, respectively. Risk stratification prior to HSCT1 and percentage of blasts before HSCT2 were independent risk factors for OS post-HSCT2, and relapse within 6 months post-HSCT1 was an independent risk factor for DFS and relapse post-HSCT2. Our findings suggest that HSCT2 could be a salvage option for patients with relapsed AL post-Chemo+m-DLI.

关键词： second hematopoietic stem cell transplantation     acute leukemia     relapse     chemotherapy     modified donor lymphocyte infusion    

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Erratum to: Soft-HGRNs: soft hierarchical graph recurrent networks for multi-agent partially observable

Yixiang REN, Zhenhui YE, Yining CHEN, Xiaohong JIANG, Guanghua SONG

《信息与电子工程前沿（英文）》 2023年 第24卷 第3期   页码 480-480 doi: 10.1631/FITEE.22e0073

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Everyone has a donor: contribution of the Chinese experience to global practice of haploidentical hematopoietic

Meng Lv, Yingjun Chang, Xiaojun Huang

《医学前沿（英文）》 2019年 第13卷 第1期   页码 45-56 doi: 10.1007/s11684-017-0595-7

摘要： Human leukocyte antigen (HLA)-matched donors for hematopoietic stem cell transplantation (HSCT) have long been scarce in China. Haploidentical (haplo) donors are available for the vast majority of patients, but toxicity has limited this approach. Three new approaches for haplo-HSCT originated from Italy, China, and USA in 1990 and have been developed to world-renowned system up to now. The Chinese approach have been greatly improved by implementing new individualized conditioning regimens, donor selection based on non-HLA systems, risk-directed strategies for graft-versus-host disease and relapse, and infection management. Haplo-HSCT has exhibited similar efficacy to HLA-matched HSCT and has gradually become the predominant donor source and the first alternative donor choice for allo-HSCT in China. Registry-based analyses and multicenter studies adhering to international standards facilitated the transformation of the unique Chinese experience into an inspiration for the refinement of global practice. This review will focus on how the new era in which “everyone has a donor” will become a reality in China.

关键词： haploidentical hematopoietic stem cell transplantation     conditioning     graft-versus-host disease     relapse     infection     donor selection    

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Propensity score-matched study and meta-analysis of cumulative outcomes of day 2/3 versus day 5/6 embryo

null

《医学前沿（英文）》 2017年 第11卷 第4期   页码 563-569 doi: 10.1007/s11684-017-0535-6

摘要：

The superiority of the cumulative outcomes of day 5/6 embryo transfer to those of day 2/3 embryo transfer in infertile couples has been debated. This retrospective study included data collected from 1051 patients from July 2011 to June 2014. Multiple maternal baseline covariates were subjected to propensity score matching analysis, and each day 5/6 group woman was matched to one day 2/3 group woman. A systematic meta-analysis was conducted to validate the results. After matching was completed, 217 patients on the day 2/3 group were matched with those on the day 5/6 group, and no significant differences in the baseline characteristics were observed between the two groups. The cumulative pregnancy rate (57.14% vs. 53.46%, OR 1.16, 95% CI 0.79–1.70) and cumulative live birth rate (53.00% vs. 49.77%, OR 1.14, 95% CI 0.78–1.66) of day 5/6 embryo transfers were higher than those of day 2/3 embryo transfers, but this difference was not significant. The mean cycles per live birth and mean days per live birth in the day 5/6 group were significantly lower than those in the day 2/3 group. This study demonstrated that day 5/6 embryo transfer is a more cost-effective and time-efficient policy than day 2/3 embryo transfer to produce a live baby.

关键词： blastocyst     embryo transfer     cumulative pregnancy rate     cumulative live birth rate     IVF    

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An isogeometric numerical study of partially and fully implicit schemes for transient adjoint shape sensitivity

Zhen-Pei WANG, Zhifeng XIE, Leong Hien POH

《机械工程前沿（英文）》 2020年 第15卷 第2期   页码 279-293 doi: 10.1007/s11465-019-0575-5

摘要： In structural design optimization involving transient responses, time integration scheme plays a crucial role in sensitivity analysis because it affects the accuracy and stability of transient analysis. In this work, the influence of time integration scheme is studied numerically for the adjoint shape sensitivity analysis of two benchmark transient heat conduction problems within the framework of isogeometric analysis. It is found that (i) the explicit approach ( = 0) and semi-implicit approach with <0.5 impose a strict stability condition of the transient analysis; (ii) the implicit approach ( =1) and semi-implicit approach with > 0.5 are generally preferred for their unconditional stability; and (iii) Crank–Nicolson type approach ( =0.5) may induce a large error for large time-step sizes due to the oscillatory solutions. The numerical results also show that the time-step size does not have to be chosen to satisfy the critical conditions for all of the eigen-frequencies. It is recommended to use for unconditional stability, such that the oscillation condition is much less critical than the Crank–Nicolson scheme, and the accuracy is higher than a fully implicit approach.

关键词： isogeometric shape optimization     design-dependent boundary condition     transient heat conduction     implicit time integration     adjoint method    

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Projections of heat-related excess mortality in China due to climate change, population and aging

《环境科学与工程前沿（英文）》 2023年 第17卷 第11期 doi: 10.1007/s11783-023-1732-y

摘要：

● Four scenarios were used to project heat-related excess mortality in China.

关键词： Heat-related excess mortality     LMDI     Aging     YLL     VSLY    

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Effects and mechanisms of acupuncture on women related health

《医学前沿（英文）》 doi: 10.1007/s11684-023-1051-5

摘要： Globally, public health interventions have resulted in a 30-year increase in women’s life expectancy. However, women’s health has not increased when socioeconomic status is ignored. Women’s health has become a major public health concern, for those women from developing countries are still struggling with infectious and labor-related diseases, and their counterparts in developed countries are suffering from physical and psychological disorders. In recent years, complementary and alternative medicine has attracted wide attentions with regards to maintaining women’s health. Acupuncture, a crucial component of traditional Chinese medicine, has been used to treat many obstetric and gynecological diseases for thousands of years due to its analgesic and anti-inflammatory effects and its effects on stimulating the sympathetic/parasympathetic nervous system. To fully understand the mechanism through which acupuncture exerts its effects in these diseases would significantly extend the list of available interventions and would allow for more reasonable advice to be given to general practitioners. Therefore, by searching PubMed and CNKI regarding the use of acupuncture in treating obstetric and gynecological diseases, we aimed to summarize the proven evidence of using acupuncture in maintaining women’s health by considering both its effectiveness and the underlying mechanisms behind its effects.

关键词： acupuncture     women health     clinical efficacy     mechanism    

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标题 作者 时间 类型 操作

Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

null

期刊论文

event-free patients receiving haploidentical allografts and those receiving human leukocyte antigen-matchedsibling donor allografts

null

期刊论文

Fate of microplastics in a coastal wastewater treatment plant: Microfibers could partially break through

期刊论文

The influence of brain death on donor liver and the potential mechanisms of protective intervention

null

期刊论文

Design and analysis of partially decoupled translational parallel mechanisms with single-loop structures

期刊论文

Regulation of radicals by hydrogen-donor solvent in direct coal liquefaction

期刊论文

Enhanced photoelectrochemical water splitting with a donor-acceptor polyimide

期刊论文

Performance enhancement of partially shaded solar PV array using novel shade dispersion technique

Namani RAKESH,T. Venkata MADHAVARAM

期刊论文

used as a salvage option for patients with relapsed acute leukemia post-chemotherapy plus modified donor

期刊论文

Erratum to: Soft-HGRNs: soft hierarchical graph recurrent networks for multi-agent partially observable

Yixiang REN, Zhenhui YE, Yining CHEN, Xiaohong JIANG, Guanghua SONG

期刊论文

Everyone has a donor: contribution of the Chinese experience to global practice of haploidentical hematopoietic

Meng Lv, Yingjun Chang, Xiaojun Huang

期刊论文

Propensity score-matched study and meta-analysis of cumulative outcomes of day 2/3 versus day 5/6 embryo

null

期刊论文

An isogeometric numerical study of partially and fully implicit schemes for transient adjoint shape sensitivity

Zhen-Pei WANG, Zhifeng XIE, Leong Hien POH

期刊论文

Projections of heat-related excess mortality in China due to climate change, population and aging

期刊论文

Effects and mechanisms of acupuncture on women related health

期刊论文